Somatostatin receptor scintigraphy is an established modality for imaging well-differentiated neuroendocrine tumors [[i]]. 68Ga DOTA peptide PET imaging is very specific method, but it can accumulate in benign inflammatory and granulomatous diseases like tuberculosis, sarcoidosis, or rheumatoid arthritis as activated macrophages and lymphocytes express somatostatin receptors on their surface [[ii]]. Studies has also shown the somatostatin receptor expression in vertebral hemangiomas [[iii],[iv]]. Vertebral hemangiomas are often incidental, predominantly show asymptomatic findings in MRI or CT scans, and are most commonly found in the thoracic spine. Histologically, they consist of thin-walled, blood-filled vessels and sinuses set in fatty marrow [[v]]. The Anatomical imaging should always be important for lesion characterization. Radiographically the classic “corduroy cloth” or “jail bar” appearance is strongly associated with vertebral hemangiomas. Axial CT will show a “polka-dotted” or “salt and pepper” appearance due to the thickened vertebral trabeculae. Although bone metastasis from NETs is very rare, without evaluation of the concurrent CT images, the vertebral tracer uptake could be interpreted as skeletal metastases. Combining the anatomic and metabolic information on PET/CT is crucial for accurate tumor staging.
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[iii]. Brogsitter C, Hofmockel T, Kotzerke J. (68)Ga DOTATATE uptake in vertebral hemangioma. Clin Nucl Med. 2014;39:462-463.
[iv]. Klinaki I, Al-Nahhas A, Soneji N, et al. 68Ga DOTATATE PET/CT uptake in spinal lesions and MRI correlation on a patient with neuroendocrine tumor: potential pitfalls. Clin Nucl Med. 2013;38:e449–e453.
[v]. Friedman DP. Symptomatic vertebral hemangiomas: MR findings. AJR Am J Roentgenol. 1996;167:359Y364.